Human WLS Recombinant Protein (RPPB5152)
- SKU:
- RPPB5152
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q5T9L3
Description
| Product Name: | Human WLS Recombinant Protein |
| Product Code: | RPPB5152 |
| Size: | 10µg |
| Species: | Human |
| Target: | WLS |
| Synonyms: | C1orf139, EVI, GPR177, MRP, Protein wntless homolog, Integral membrane protein GPR177, Protein evenness interrupted homolog, Putative NF-kappa-B-activating protein 373, WLS. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | WLS protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0),0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEMSPWF QFMLFILQLD IAFKLNNQIR ENAEVSMDVS LAYRDDAFAE WTEMAHERVP RKLKCTFTSP KTPEHEGRYY ECDVLPFMEI GSVAHKFYLL NIRLPVNEKK KINVGIGEIK DIRLVGIHQN GGFTK |
WLS (Wnt trafficking regulator) is a multipass transmembrane protein which regulates the sorting and secretion of Wnt protein. WLS is necessitated for organogenesis during embryogenesis and for the establishment of the anterior-posterior axis. WLS is encoded by a gene which maps to human chromosome 1 and is expressed as multiple alternatively spliced isoforms. WLS promotes various cancers such as glioma tumourigenesis.
WLS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (101-232a.a) and having a molecular mass of 17.8kDa. WLS is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. |
| UniProt Code: | Q5T9L3 |
| NCBI GenInfo Identifier: | 301069320 |
| NCBI Gene ID: | 79971 |
| NCBI Accession: | NP_001002292.3 |
| UniProt Secondary Accession: | Q5T9L3,Q5JRS7, Q7Z2Z9, Q8NC43, B2RNT2, |
| UniProt Related Accession: | Q5T9L3 |
| Molecular Weight: | 62 kDa |
| NCBI Full Name: | protein wntless homolog isoform 2 |
| NCBI Synonym Full Names: | Wnt ligand secretion mediator |
| NCBI Official Symbol: | WLS�� |
| NCBI Official Synonym Symbols: | EVI; MRP; GPR177; mig-14; C1orf139�� |
| NCBI Protein Information: | protein wntless homolog |
| UniProt Protein Name: | Protein wntless homolog |
| UniProt Synonym Protein Names: | Integral membrane protein GPR177; Protein evenness interrupted homolog; EVI; Putative NF-kappa-B-activating protein 373 |
| Protein Family: | Protein wntless |
| UniProt Gene Name: | WLS�� |
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