Human VOPP1 Recombinant Protein (RPPB5127)
- SKU:
- RPPB5127
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96AW1
Description
| Product Name: | Human VOPP1 Recombinant Protein |
| Product Code: | RPPB5127 |
| Size: | 10µg |
| Species: | Human |
| Target: | VOPP1 |
| Synonyms: | Vesicular overexpressed in cancer prosurvival protein 1, EGFR-coamplified and overexpressed protein, ECop, Glioblastoma-amplified secreted protein, Putative NF-kappa-B-activating protein 055N, VOPP1, ECOP, GASP, FLJ20532, DKFZp564K0822. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The VOPP1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.2M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK |
Vesicular overexpressed in cancer prosurvival protein 1 (VOPP1) has been previously shown to be over-expressed in human glioblastoma multiform and squamous cell carcinoma. VOPP1 is a crucial regulator of NF-kappaB signaling, and this high-level, amplification-mediated VOPP1 expression, such as that occurring in tumors with amplified EGFR, might impact the resistance to apoptosis.
VOPP1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 112 amino acids (82-172 a.a.) and having a molecular mass of 12kDa. The VOPP1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ECOP: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. Belongs to the VOPP1/ECOP family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7p11.2Cellular Component: cytoplasmic vesicle membrane; endosomeMolecular Function: signal transducer activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96AW1 |
| NCBI GenInfo Identifier: | 74760714 |
| NCBI Gene ID: | 81552 |
| NCBI Accession: | Q96AW1.1 |
| UniProt Secondary Accession: | Q96AW1,Q6FIE3, Q8NBN8, Q96RE5, Q9H0W4, B0AZU1, B2RAT4 B3KS72, C9JWR3 |
| UniProt Related Accession: | Q96AW1 |
| Molecular Weight: | 17,381 Da |
| NCBI Full Name: | Vesicular, overexpressed in cancer, prosurvival protein 1 |
| NCBI Synonym Full Names: | vesicular, overexpressed in cancer, prosurvival protein 1 |
| NCBI Official Symbol: | VOPP1�� |
| NCBI Official Synonym Symbols: | ECOP; GASP�� |
| NCBI Protein Information: | vesicular, overexpressed in cancer, prosurvival protein 1 |
| UniProt Protein Name: | Vesicular, overexpressed in cancer, prosurvival protein 1 |
| UniProt Synonym Protein Names: | EGFR-coamplified and overexpressed protein; ECop; Glioblastoma-amplified secreted protein; Putative NF-kappa-B-activating protein 055N |
| Protein Family: | Vesicular, overexpressed in cancer, prosurvival protein |
| UniProt Gene Name: | VOPP1�� |
| UniProt Entry Name: | VOPP1_HUMAN |
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