Human Von Hippel Lindau / VHL ELISA Kit

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SKU:
HUFI01668
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P40337
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
VHL, Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, RCA1, VHL1, pVHL, HRCA1
Reactivity:
Human
Research Area:
Signal Transduction

Description

Human Von Hippel Lindau / VHL ELISA

VHL (Von Hippel-Lindau Tumor Suppressor) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. Mutations of VHL are associated with renal cell carcinoma, clear-cell sarcoma, and endolymphatic sac tumors. In normal cells, this protein product ubiquitinates hypoxia-inducible factor (HIF), targeting it for destruction via the proteasome under normoxic conditions. The VHL protein functions as a tumor suppressor by negatively regulating cellular responses to hypoxia.

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