Human VBP1 Recombinant Protein (RPPB5115)
- SKU:
- RPPB5115
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61758
Description
| Product Name: | Human VBP1 Recombinant Protein |
| Product Code: | RPPB5115 |
| Size: | 20µg |
| Species: | Human |
| Target: | VBP1 |
| Synonyms: | Prefoldin subunit 3, HIBBJ46, Von Hippel-Lindau-binding protein 1, VBP-1, VHL-binding protein 1, VBP1, PFDN3, PFD3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | VBP1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAAVKDS CGKGEMATGN GRRLHLGIPE AVFVEDVDSF MKQPGNETAD TVLKKLDEQY QKYKFMELNL AQKKRRLKGQ IPEIKQTLEI LKYMQKKKES TNSMETRFLL ADNLYCKASV PPTDKVCLWL GANVMLEYDI DEAQALLEKN LSTATKNLDS LEEDLDFLRD QFTTTEVNMA RVYNWDVKRR NKDDSTKNKA |
Prefoldin subunit 3 (VBP1) is a member of the prefoldin subunit alpha family. VBP1 interacts with the Von Hippel-Lindau protein in order to create an intracellular complex. Since VBP1 serves as a chaperone protein, it is assumed to have a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. VBP1 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. VBP1 also binds to nascent polypeptide chain and stimulates folding in an environment in which there are numerous competing pathways for nonnative proteins.
VBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-197 a.a) and having a molecular mass of 25kDa.VBP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. |
| NCBI Summary: | The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P61758 |
| NCBI GenInfo Identifier: | 746816135 |
| NCBI Gene ID: | 7411 |
| NCBI Accession: | NP_001290472.1 |
| UniProt Secondary Accession: | P61758,O55228, Q15765, Q5JT81, Q86X96, B2R8L5, |
| UniProt Related Accession: | P61758 |
| Molecular Weight: | |
| NCBI Full Name: | prefoldin subunit 3 isoform 2 |
| NCBI Synonym Full Names: | VHL binding protein 1 |
| NCBI Official Symbol: | VBP1�� |
| NCBI Official Synonym Symbols: | PFD3; PFDN3; VBP-1; HIBBJ46�� |
| NCBI Protein Information: | prefoldin subunit 3 |
| UniProt Protein Name: | Prefoldin subunit 3 |
| UniProt Synonym Protein Names: | HIBBJ46; von Hippel-Lindau-binding protein 1; VBP-1; VHL-binding protein 1 |
| UniProt Gene Name: | VBP1�� |
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