Human USP46 Recombinant Protein (RPPB5097)
- SKU:
- RPPB5097
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62068
Description
| Product Name: | Human USP46 Recombinant Protein |
| Product Code: | RPPB5097 |
| Size: | 10µg |
| Species: | Human |
| Target: | USP46 |
| Synonyms: | Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The USP46 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTVRNIA SICNMGTNAS ALEKDIGPEQ FPINEHYFGL VNFGNTCYCN SVLQALYFCR PFRENVLAYK AQQKKKENLL TCLADLFHSI ATQKKKVGVI PPKKFISRLR KENDLFDNYM QQDAHEFLNY LLNTIADILQ EEKKQEKQNG KLKNGNMNEP AENNKPELTW VHEIFQGTLT NETRCLNCET VSSKDEDFLD LSVDVEQNTS ITHCLRDFSN TETLCSEQKY YCETCCSKQE AQKRMRVKKL PMILALHLKR FKYMEQLHRY TKLSYRVVFP LELRLFNTSS DAVNLDRMYD LVAVVVHCGS GPNRGHYITI VKSHGFWLLF DDDIVEKIDA QAIEEFYGLT SDISKNSESG YILFYQSRE |
USP46 is a part of a large family of cysteine proteases that function as deubiquitinating enzymes which interacts with WDR48 to have a high activity. USP46 operates by mediating the deubiquitination of GAD1/GAD67.
USP46 Human Recombinant produced in E. coli is. a single polypeptide chain containing 389 amino acids (1-366) and having a molecular mass of 44.8kDa. USP46 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | USP46: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.19.12; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 4q12 Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; behavioral fear response; righting reflex; adult feeding behavior; behavioral response to ethanol; regulation of synaptic transmission, GABAergic |
| NCBI Summary: | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | P62068 |
| NCBI GenInfo Identifier: | 49065850 |
| NCBI Gene ID: | 64854 |
| NCBI Accession: | P62068.1 |
| UniProt Secondary Accession: | P62068,Q80V95, Q9H7U4, Q9H9T8, B7Z3Y7, B7Z675, B7Z7S3 G8ACC7, |
| UniProt Related Accession: | P62068 |
| Molecular Weight: | 366 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 46 |
| NCBI Official Symbol: | USP46�� |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; deubiquitinating enzyme 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP46�� |
| UniProt Entry Name: | UBP46_HUMAN |
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