Human TSR2 Recombinant Protein (RPPB5033)
- SKU:
- RPPB5033
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q969E8
Description
| Product Name: | Human TSR2 Recombinant Protein |
| Product Code: | RPPB5033 |
| Size: | 10µg |
| Species: | Human |
| Target: | TSR2 |
| Synonyms: | TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae), WGGMotif Containing 1, Pre-RRNA-Processing Protein TSR2 Homolog, DT1P1A10, DBA14, WGG1,Pre-rRNA-processing protein TSR2 homolog. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TSR2 protein solution (0.5mg/ml) containing PBS buffer(pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAGAAED ARALFRAGVC AALEAWPALQ IAVENGFGGV HSQEKAKWLGGAVEDYFMRN ADLELDEVED FLGELLTNEF DTVVEDGSLP QVSQQLQTMF HHFQRGDGAA LREMASCITQRKCKVTATAL KTARETDEDE DDVDSVEEME VTATNDGAAT DGVCPQPEPS DPDAQTIKEE DIVEDGWTIV RRK |
TSR2 is part of the TSR2 family. TSR2 is involved in 20S pre-rRNAprocessing. Among the diseases which are associated with TSR2 are blepharospasm anddiamond-blackfan anemia.
TSR2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a) andhaving a molecular mass of 23.2kDa.TSR2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TSR2: May be involved in 20S pre-rRNA processing (Potential). Belongs to the TSR2 family.Chromosomal Location of Human Ortholog: Xp11.22Cellular Component: nucleusMolecular Function: protein bindingBiological Process: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Disease: Diamond-blackfan Anemia 14 With Mandibulofacial Dysostosis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q969E8 |
| NCBI GenInfo Identifier: | 24308388 |
| NCBI Gene ID: | 90121 |
| NCBI Accession: | NP_477511.1 |
| UniProt Secondary Accession: | Q969E8 |
| UniProt Related Accession: | Q969E8 |
| Molecular Weight: | 21 kDa |
| NCBI Full Name: | pre-rRNA-processing protein TSR2 homolog isoform a |
| NCBI Synonym Full Names: | TSR2 ribosome maturation factor |
| NCBI Official Symbol: | TSR2�� |
| NCBI Official Synonym Symbols: | WGG1; DBA14; DT1P1A10�� |
| NCBI Protein Information: | pre-rRNA-processing protein TSR2 homolog |
| UniProt Protein Name: | Pre-rRNA-processing protein TSR2 homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Pre-rRNA-processing protein |
| UniProt Gene Name: | TSR2�� |
| UniProt Entry Name: | TSR2_HUMAN |
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