Cytokines Recombinant Proteins

Human TSLPR Recombinant Protein (RPPB1047)

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SKU:
RPPB1047
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9HC73
Research Area:
Cytokines

Description

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Product Name:Human TSLPR Recombinant Protein
Product Code:RPPB1047
Size:20µg
Species:Human
Target:TSLPR
Synonyms:CRL2, CRLF2Y, Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR, ILXR.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:TSLPR protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined�by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SK

Thymic Stromal Lymphopoietin Receptor (TSLPR) is a member of the type I cytokine receptor family. TSLPR alongside the interleukin 7 receptor (IL7R) activate STAT3, STAT5, and JAK2 pathways, which is regulated processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding dissimilar isoforms have been found for this gene. TSLPR is expressed in heart, skeletal muscle, kidney and adult and fetal liver.

TSLPR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (23-231 a.a.) and having a molecular mass of 26.6kDa.TSLPR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2

NCBI Summary:This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Code:Q9HC73
NCBI GenInfo Identifier:38257768
NCBI Gene ID:64109
NCBI Accession:Q9HC73.1
UniProt Secondary Accession:Q9HC73,Q5G7M1, Q9H5R3, J3QKD1,
UniProt Related Accession:Q9HC73
Molecular Weight:29,360 Da
NCBI Full Name:Cytokine receptor-like factor 2
NCBI Synonym Full Names:cytokine receptor-like factor 2
NCBI Official Symbol:CRLF2��
NCBI Official Synonym Symbols:CRL2; TSLPR; CRLF2Y��
NCBI Protein Information:cytokine receptor-like factor 2
UniProt Protein Name:Cytokine receptor-like factor 2
UniProt Synonym Protein Names:Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor
Protein Family:Thymic stromal lymphopoietin
UniProt Gene Name:CRLF2��
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