Human TSFM Recombinant Protein (RPPB5028)
- SKU:
- RPPB5028
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P43897
Description
| Product Name: | Human TSFM Recombinant Protein |
| Product Code: | RPPB5028 |
| Size: | 20µg |
| Species: | Human |
| Target: | TSFM |
| Synonyms: | Elongation factor Ts, mitochondrial, Ts Translation Elongation Factor Mitochondrial, TSFM, EF-Ts, EF-TsMt, COXPD3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TSFM protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSKELLMKLR RKTGYSFVNC KKALETCGGD LKQAEIWLHK EAQKEGWSKA AKLQGRKTKE GLIGLLQEGN TTVLVEVNCE TDFVSRNLKF QLLVQQVALG TMMHCQTLKD QPSAYSKVQW LTPVNLALWE AEAGGSLEGF LNSSELSGLP AGPDREGSLK DQLALAIGKL GENMILKRAA WVKVPSGFYV GSYVHGAMQS PSLHKLVLGK YGALVICETS EQKTNLEDVG RRLGQHVVGM APLSVGSLDD EPGGEAETKM LSQPYLLDPS ITLGQYVQPQ GVSVVDFVRF ECGEGEEAAE TE |
TSFM is a mitochondrial translation elongation factor which is linked with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. TSFM stays bound to the aminoacyl-tRNA.EF-Tu.GTP complex until the GTP hydrolysis stage on the ribosome. Mutations in TSFM are related with combined oxidative phosphorylation deficiency-3 syndrome.
TSFM Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (46-346 a.a) and having a molecular mass of 32.9kDa.TSFM is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EFT5: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3). Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes. Belongs to the EF-Ts family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation elongation; Translation Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: mitochondrial matrix; mitochondrion; nucleus Molecular Function:translation elongation factor activity Biological Process: regulation of RNA elongation; translational elongation Disease: Combined Oxidative Phosphorylation Deficiency 3 |
| NCBI Summary: | This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010] |
| UniProt Code: | P43897 |
| NCBI GenInfo Identifier: | 12644268 |
| NCBI Gene ID: | 10102 |
| NCBI Accession: | P43897.2 |
| UniProt Secondary Accession: | P43897,Q561V7, Q8TBC2, Q9UQK0, B4E391, F5H2T7, |
| UniProt Related Accession: | P43897 |
| Molecular Weight: | 23,557 Da |
| NCBI Full Name: | Elongation factor Ts, mitochondrial |
| NCBI Synonym Full Names: | Ts translation elongation factor, mitochondrial |
| NCBI Official Symbol: | TSFM�� |
| NCBI Official Synonym Symbols: | EFTS; EFTSMT�� |
| NCBI Protein Information: | elongation factor Ts, mitochondrial |
| UniProt Protein Name: | Elongation factor Ts, mitochondrial |
| UniProt Gene Name: | TSFM�� |
| UniProt Entry Name: | EFTS_HUMAN |
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