Cytokines Recombinant Proteins

Human TRAIL (114-281 a.a.) Recombinant Protein (RPPB1055)

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SKU:
RPPB1055
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P50591
Research Area:
Cytokines

Description

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Product Name:Human TRAIL (114-281 a.a.) Recombinant Protein
Product Code:RPPB1055
Size:50µg
Species:Human
Target:TRAIL (114-281 a.a.)
Synonyms:Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL, Apo-2 ligand, Apo-2L, CD253 antigen, TL2, APO2L, TNFSF10.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless liquid.
Formulation:1mg/ml in 20mM Tris-HCl pH-7.5, 300mM NaCl, 0.1mM DTT & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNGELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWSKDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG

TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.In humans, the gene that encodes for TRAIL is located at chromosome 3q26.TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.

Soluble TNF-related apoptosis-inducing ligand Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (114-281) and having a molecular mass of 19.6 kDa.The sTRAIL is purified by proprietary chromatographic techniques.

UniProt Protein Function:Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:P50591
NCBI GenInfo Identifier:1730015
NCBI Gene ID:8743
NCBI Accession:P50591.1
UniProt Secondary Accession:P50591,A1Y9B3,
UniProt Related Accession:P50591
Molecular Weight:11,746 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 10
NCBI Synonym Full Names:TNF superfamily member 10
NCBI Official Symbol:TNFSF10��
NCBI Official Synonym Symbols:TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A��
NCBI Protein Information:tumor necrosis factor ligand superfamily member 10
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 10
UniProt Synonym Protein Names:Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253
UniProt Gene Name:TNFSF10��
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