Human TNFAIP3 / TNF alpha-induced protein 3 ELISA Kit

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SKU:
HUFI02161
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P21580
Sensitivity:
0.188ng/ml
Range:
0.313-20ng/ml
ELISA Type:
Sandwich
Synonyms:
TNFAIP3, OTUD7C, TNFA1P2, A20TNFA1P2, EC 3.4.19.12, EC 6.3.2.-, OTU domain-containing protein 7C, Putative DNA-binding protein A20, TNF alpha-induced protein 3, tumor necrosis factor alpha-induced protein 3, tumor necrosis factor inducible protein A2
Reactivity:
Human
Research Area:
Cell Death

Description

Human TNFAIP3 / TNF alpha-induced protein 3 ELISA

TNFAIP3 (TNF Alpha Induced Protein 3), also known as A20, is a protein which in humans is encoded by the TNFAIP3 gene. TNFAIP3 is a negative regulator of inflammation and its expression is increased by pro-inflammatory cytokines such as TNF-alpha, IL-1 beta and IFN-gamma. The protein localizes to the cytoplasm and nucleus, where it functions as an E3 ubiquitin ligase that targets proteins for proteasomal degradation. A20 has been shown to be a key regulator of the inflammatory response. Mutations in the TNFAIP3 gene have been associated with autoinflammatory diseases such as familial Mediterranean fever and Sjögren's syndrome.

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