Human TANK (1-119) Recombinant Protein (RPPB4905)

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SKU:
RPPB4905
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q92844

Description

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Product Name:Human TANK (1-119) Recombinant Protein
Product Code:RPPB4905
Size:50µg
Species:Human
Target:TANK (1-119)
Synonyms:TRAF2, I-TRAF, TANK, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, ITRAF.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The TANK protein solution contains 20mM Tris, pH-8.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI

TRAF2 protein is related with transduce signals from members of the TNFR superfamily. TRAF2 is located in the cytoplasm binds to TRAF1, TRAF2, or TRAF3, thus inhibiting TRAF function by sequestering the TRAFs in a suppressed state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1. TRAF2 is necessary for the cellular response to TNF-alpha by connecting upstream signalling molecules to the IKKs and p65.

TANK produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (1-119 a.a.) and having a molecular mass of 13.6 kDa.TANK is purified by proprietary chromatographic techniques.

UniProt Protein Function:TANK: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: cytoplasm; cytosol

Molecular Function:metal ion binding; protein binding; ubiquitin protein ligase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; innate immune response; MyD88-independent toll-like receptor signaling pathway; signal transduction; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway

NCBI Summary:The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Code:Q92844
NCBI GenInfo Identifier:143811466
NCBI Gene ID:10010
NCBI Accession:Q92844.2
UniProt Secondary Accession:Q92844,Q7Z4J6, Q92885, D3DPB5,
UniProt Related Accession:Q92844
Molecular Weight:13,626 Da
NCBI Full Name:TRAF family member-associated NF-kappa-B activator
NCBI Synonym Full Names:TRAF family member associated NFKB activator
NCBI Official Symbol:TANK��
NCBI Official Synonym Symbols:ITRAF; TRAF2; I-TRAF��
NCBI Protein Information:TRAF family member-associated NF-kappa-B activator
UniProt Protein Name:TRAF family member-associated NF-kappa-B activator
UniProt Synonym Protein Names:TRAF-interacting protein; I-TRAF
Protein Family:Tankyrase
UniProt Gene Name:TANK��
UniProt Entry Name:TANK_HUMAN
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