Human TACSTD2 Recombinant Protein (RPPB4897)

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RPPB4897

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Product Name:Human TACSTD2 Recombinant Protein
Product Code:RPPB4897
Size:25µg
Species:Human
Target:TACSTD2
Synonyms:EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TACSTD2 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQDNCTCP TNKMTVCSPD GPGGRCQCRA LGSGMAVDCS TLTSKCLLLK ARMSAPKNAR TLVRPSEHAL VDNDGLYDPD CDPEGRFKAR QCNQTSVCWC VNSVGVRRTD KGDLSLRCDE LVRTHHILID LRHRPTAGAF NHSDLDAELR RLFRERYRLH PKFVAAVHYE QPTIQIELRQ NTSQKAAGDV DIGDAAYYFE RDIKGESLFQ GRGGLDLRVR GEPLQVERTL IYYLDEIPPK FSMKRLT

Tumor-associated calcium signal transducer 2 (TACSTD2), is a member of to the EPCAM family. TACSTD2 is an intronless gene which encodes a carcinoma-associated antigen. TACSTD2 may act as a growth factor receptor and as a cell surface receptor that transduces calcium signals. Mutations of TACSTD2 have been associated with gelatinous drop-like corneal dystrophy.

TACSTD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 267 amino acids (31-274a.a.) and having a molecular mass of 29.9kDa. TACSTD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: basal plasma membrane; cytosol; extracellular space; integral to plasma membrane; lateral plasma membrane; membrane; nucleus

Molecular Function:protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation

Disease: Corneal Dystrophy, Gelatinous Drop-like

NCBI Summary:This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
UniProt Code:P09758
NCBI GenInfo Identifier:160113102
NCBI Gene ID:4070
NCBI Accession:P09758.3
UniProt Secondary Accession:P09758,Q15658, Q6FG48, Q7Z7Q4, Q96QD2,
UniProt Related Accession:P09758
Molecular Weight:35,709 Da
NCBI Full Name:Tumor-associated calcium signal transducer 2
NCBI Synonym Full Names:tumor-associated calcium signal transducer 2
NCBI Official Symbol:TACSTD2��
NCBI Official Synonym Symbols:EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1��
NCBI Protein Information:tumor-associated calcium signal transducer 2
UniProt Protein Name:Tumor-associated calcium signal transducer 2
UniProt Synonym Protein Names:Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
Protein Family:Tumor-associated calcium signal transducer
UniProt Gene Name:TACSTD2��
UniProt Entry Name:TACD2_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P09758
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