Human SULT1A3 Recombinant Protein (RPES1614)
- SKU:
- RPES1614
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human SULT1A3 Recombinant Protein
SULT1A3 belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are different in their tissue distributions and substrate specificities while their gene structure (number and length of exons) is similar. SULT1A3 gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. It is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). SULT1A3 is expressed in liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte. SULT1A3 is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
| Product Name: | Human SULT1A3 Recombinant Protein (RPES1614) |
| Product Code: | RPES1614 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Sulfotransferase 1A3/1A4, ST1A3/ST1A4, Aryl Sulfotransferase 1A3/1A4, Catecholamine-Sulfating Phenol Sulfotransferase, HAST3, M-PST, Monoamine-Sulfating Phenol Sulfotransferase, Placental Estrogen Sulfotransferase, Sulfotransferase Monoamine-Preferring, Thermolabile Phenol Sulfotransferase, TL-PST, SULT1A3, STM, SULT1A4,HAST,HAST3,M-PST,ST1A5,STM |
| Accession: | NP_808220.1 |
| Sequence: | Glu2-Leu295 |
| Fusion tag: | N-His |
| Activity: | Measured by its ability to transfer sulfate from PAPS to 1-Napthol.The specific activity is > 150 pmoles/min/µg. |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the mature form of human SULT1A3 (NP_808220.1) (Glu2-Leu295) was expressed with a polyhistide tag at the N-terminus. |
| Purity: | > 94 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 30.5 kDa |
| AP Mol Mass: | 34 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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