Epigenetics & Nuclear Signaling Recombinant Proteins
Human STUB1 Recombinant Protein (RPES2603)
- SKU:
- RPES2603
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Epigenetics & Nuclear Signaling
Description
Human STUB1 Recombinant Protein
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. The protein CHIP is highly expressed in the muscles, heart, pancreas, brain and placenta. The TPR domain of CHIP interacts with molecular chaperones Hsc70-Hsp70 and Hsp90, causing client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. The transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation is mediated by CHIP. CHIP is involved in base-excision repair: it increases the HUWE1/ARF-BP1 dependent monoubiquitination, which causes POLB degradation by the proteasome. It may also modulate receptor stability and activity via the proteasome. Human STUB1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human STUB1 Recombinant Protein (RPES2603) |
| Product Code: | RPES2603 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP |
| Accession: | Q9UNE7 |
| Sequence: | Met 1-Tyr303 |
| Fusion tag: | |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human E3 Ubiquitin-Protein Ligase CHIP is produced by our E.coli expression system and the target gene encoding Met1-Tyr303 is expressed. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 34.9 kDa |
| AP Mol Mass: | 33 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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