Cell Biology Recombinant Proteins
Human SRC Kinase/c-SRC Recombinant Protein (RPES1553)
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- SKU:
- RPES1553
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
Description
system_update_altDatasheet
Human SRC Kinase/c-SRC Recombinant Protein
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
| Product Name: | Human SRC Kinase/c-SRC Recombinant Protein (RPES1553) |
| Product Code: | RPES1553 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | ASV,c-SRC,p60-Src,SRC1 |
| Accession: | P12931-1 |
| Sequence: | Met 1-Leu 536 |
| Fusion tag: | N-His & GST |
| Activity: | The specific activity was determined to be ?80 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human SRC (P12931-1) (Met 1-Leu 536) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 87.7 kDa |
| AP Mol Mass: | 81 kDa |
| Formulation: | Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 20% gly, 0.3mM DTT |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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