Human Sonic Hedgehog/SHH Recombinant Protein (RPES4771)

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SKU:
RPES4771
Product Type:
Recombinant Protein
Species:
Human

Description

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Human Sonic Hedgehog/SHH Recombinant Protein

Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The Indian Hedgehog (IHH) and Desert Hedgehog (DHH) are the other two members of the family. The hedgehog proteins are critical signaling molecules in embryonic development. SHH is expressed in many embryonic tissues and has important functions in patterning numerous systems including limbs and the brain. SHH also plays a key function in adulthood; it is involved in the division of adult stem cells, as well as the development of some cancer and other maladies. Human SHH is expressed as a 45kDa precursor; and undergoes a series of processing during secretion. After the removal of the signal peptide; a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface; which releases the repression of the activity of Smoothened (Smo); a G-protein coupled receptor; by Ptc. Human Sonic Hedgehog/SHH Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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