Human SNIP1 Recombinant Protein (RPPB5920)
- SKU:
- RPPB5920
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8TAD8
Description
| Product Name: | Human SNIP1 Recombinant Protein |
| Product Code: | RPPB5920 |
| Size: | 20µg |
| Species: | Human |
| Target: | SNIP1 |
| Synonyms: | Smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, SNIP1, FLJ12553, dJ423B22.2, RP3-423B22.3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SNIP1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 20% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS |
SNIP1 is smad nuclear interacting protein that contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 is an inhibitor of the TGF-beta signal transduction pathway and is significant in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1.
SNIP1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 160 amino acids (258-396 a.a.) and having a molecular mass of 18.8kDa. The SNIP1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SNIP1: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period. |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding Biological Process: miRNA-mediated gene silencing, production of miRNAs; I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent Disease: Psychomotor Retardation, Epilepsy, And Craniofacial Dysmorphism |
| NCBI Summary: | This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q8TAD8 |
| NCBI GenInfo Identifier: | 48428655 |
| NCBI Gene ID: | 79753 |
| NCBI Accession: | Q8TAD8.1 |
| UniProt Related Accession: | Q8TAD8 |
| Molecular Weight: | 46 kDa |
| NCBI Full Name: | Smad nuclear-interacting protein 1 |
| NCBI Synonym Full Names: | Smad nuclear interacting protein 1 |
| NCBI Official Symbol: | SNIP1�� |
| NCBI Official Synonym Symbols: | PML1; PMRED�� |
| NCBI Protein Information: | smad nuclear-interacting protein 1 |
| UniProt Protein Name: | Smad nuclear-interacting protein 1 |
| UniProt Synonym Protein Names: | FHA domain-containing protein SNIP1 |
| Protein Family: | Smad nuclear interacting protein |
| UniProt Gene Name: | SNIP1�� |
| UniProt Entry Name: | SNIP1_HUMAN |
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