Immunology Recombinant Proteins

Human SLAMF5/CD84 Recombinant Protein (RPES5069)

(No reviews yet) Write a Review
SKU:
RPES5069

Description

system_update_altDatasheet

Human SLAMF5/CD84 Recombinant Protein

SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family. SLAM family proteins regulate multiple aspects of immune system function. Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains,a 21 aa transmembrane segment, and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs). CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain. Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation. LPS-induced macrophage activation,T cell proliferation and IFN-?production, and the interactions between T cells and B cells that are required for germinal center formation.

Product Name:Human SLAMF5/CD84 Recombinant Protein (RPES5069)
Product Code:RPES5069
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:SLAM family member 5, Cell surface antigen MAX.3, Hly9-beta, Leukocyte differentiation antigen CD84, Signaling lymphocytic activation molecule 5, CD84, SLAMF5,hCD84,LY9B,mCD84
Accession:Q9UIB8
Sequence:Lys22-Arg220
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human SLAM Family Member 5 is produced by our Mammalian expression system and the target gene encoding Lys22-Arg220 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:23.1 kDa
AP Mol Mass:35-43 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology
View AllClose

Related Products