Cytokines Recombinant Proteins
Human sIL6R Recombinant Protein (RPPB0536)
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- SKU:
- RPPB0536
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P08887
- Research Area:
- Cytokines
Description
| Product Name: | Human sIL6R Recombinant Protein |
| Product Code: | RPPB0536 |
| Size: | 10µg |
| Species: | Human |
| Target: | sIL6R |
| Synonyms: | IL6R-alpha, CD126, IL-6R 1, CD126 antigen, IL6RA, Interleukin 6 receptor, Interleukin 6 receptor alpha subunit, Interleukin-6 receptor alpha chain precursor, B cell stimulatory factor-2, Membrane glycoprotein 80, gp80, IL-6R, MGC104991. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | sIL6R protein solution (0.25mg/ml) contains 10% glycerol & Phosphate buffered saline (pH7.4).� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPLAPRRCP AQEVARGVLT SLPGDSVTLT CPGVEPEDNA TVHWVLRKPA AGSHPSRWAG MGRRLLLRSV QLHDSGNYSC YRAGRPAGTV HLLVDVPPEE PQLSCFRKSP LSNVVCEWGP RSTPSLTTKA VLLVRKFQNS PAEDFQEPCQ YSQESQKFSC QLAVPEGDSS FYIVSMCVASSVGSKFSKTQ TFQGCGILQP DPPANITVTA VARNPRWLSV TWQDPHSWNS SFYRLRFELR YRAERSKTFT TWMVKDLQHH CVIHDAWSGL RHVVQLRAQE EFGQGEWSEW SPEAMGTPWT ESRSPPAENE VSTPMQALTT NKDDDNILFR DSANATSLPV QDSSSVPLPH HHHHH |
| Biological Activity: | Measured by its ability to inhibit proliferation using M1 mouse myeloid leukemia cells. The ED50 range ? 20 ng/ml with Human IL-6. |
The IL-6 receptor complex is composed of two membrane glycoproteins: the low affinity receptor and the signaltransducing component. The soluble form of IL6R is found in the urine of healthy adult humans and the serum of HIV positive individuals, as well as in the cell culture supernatants of stimulated PBMC�s. This soluble form of IL6R results from either proteolytic cleavage from the membrane, or an isoform derived splice variant.
sIL6R produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (20-365 a.a.) and fused to a 9 aa His Tag at C-terminus containing a total of 355 amino acids and having a molecular mass of 39.6kDa.sIL6R shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. |
| NCBI Summary: | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] |
| UniProt Code: | P08887 |
| NCBI GenInfo Identifier: | 124343 |
| NCBI Gene ID: | 3570 |
| NCBI Accession: | P08887.1 |
| UniProt Secondary Accession: | P08887,Q16202, Q53EQ7, Q5FWG2, Q5VZ23, A8KAE8, B2R6V4 |
| UniProt Related Accession: | P08887 |
| Molecular Weight: | 40,237 Da |
| NCBI Full Name: | Interleukin-6 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 6 receptor |
| NCBI Official Symbol: | IL6R�� |
| NCBI Official Synonym Symbols: | IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1�� |
| NCBI Protein Information: | interleukin-6 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-6 receptor subunit alpha |
| UniProt Synonym Protein Names: | IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126 |
| Protein Family: | Interleukin-6 receptor |
| UniProt Gene Name: | IL6R�� |
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