Human S100A2 Recombinant Protein (RPES0800)

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SKU:
RPES0800
Product Type:
Recombinant Protein
Species:
Human

Description

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Human S100A2 Recombinant Protein

The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21; and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney; and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium; and the active form functions in regulating cell proliferation and differentiation; gene transcription; and p53-dependent growth arrest and apoptosis. Accordingly; this protein is regarded as a putative tumor suppressor; and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

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