Human RHEB Recombinant Protein (RPES0127)
- SKU:
- RPES0127
- Product Type:
- Recombinant Protein
- Species:
- Human
Frequently bought together:
Description
system_update_altDatasheet
Human RHEB Recombinant Protein
GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored; cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle; and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling; and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form; farnesylation of the protein is required for this activity.
| Product Name: | Human RHEB Recombinant Protein (RPES0127) |
| Product Code: | RPES0127 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | GTP-Binding Protein Rheb, Ras Homolog Enriched in Brain, RHEB, RHEB2 |
| Accession: | Q15382 |
| Sequence: | Met1-Met184 |
| Fusion tag: | N-GST |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human RHEB is produced by our E.coli expression system and the target gene encoding Met1-Met184 is expressed with a GST tag at the N-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 20.4 kDa |
| AP Mol Mass: | 45 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM Tris; 10mM GSH; pH 8.0. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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