Human PXR / NR1I2 ELISA Kit

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SKU:
HUFI00939
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
O75469
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
PXR, Pregnane X Receptor, NR1I2, Nuclear receptor subfamily 1 group I member 2, Steroid and xenobiotic receptor, SXR, Pregnane X receptor, Orphan nuclear receptor PAR,, Orphan nuclear receptor PXR
Reactivity:
Human
Research Area:
Epigenetics and Nuclear Signaling

Description

Human PXR / NR1I2 ELISA Kit

PXR/NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4. It is activated by a variety of drugs that promote CYP3A4. Alternative splicing of this gene has produced many alternatively spliced transcripts, some of which include non-AUG (CUG) translation start codon. Additional transcript variants have been characterized, but they haven't been completely analyzed. Cerebrotendinous Xanthomatosis and Biliary Tract Disease are two examples of diseases associated with NR1I2.

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