Metabolism Recombinant Proteins

Human PSPH Recombinant Protein (RPES4876)

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SKU:
RPES4876
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism

Description

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Human PSPH Recombinant Protein

Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. The rate-limiting enzyme in l-serine synthesis is PSPH. It's been shown that phosphoserine phosphatase (PSPH) is involved in skin homeostasis. Phosphoserine phosphatase (PSP) cleaves phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been studied in human-mouse somatic cell hybrids with various combinations of human chromosomes. The enzyme phosphoserine phosphatase (PSPH) is present in the proliferative layer of rodents and humans' skin, as well as hair follicles, and is highly induced in SCC. In keratinocytes, the protein phosphoserine phosphatase (PSPH) is a cytoplasmic enzyme that is found in endosomes and is mostly homodimerized. Knock down of phosphoserine phosphatase (PSPH) dramatically diminished SCC cell proliferation and cyclin D1 levels in the presence of exogenous of l-serine production suggesting a non-canonical role for phosphoserine phosphatase (PSPH) in epithelial carcinogenesis. Phosphoserine phosphatase (PSPH) is selectively expressed in proliferative normal keratinocytes and skin tumors. Phosphoserine phosphatase (PSPH) appears to be critical for the SCC cell proliferation, but this effect may not be linked to the phosphserine metabolic pathway. Human PSPH Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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