Epigenetics & Nuclear Signaling Recombinant Proteins
Human PPIase/FKBP7 Recombinant Protein (RPES4155)
- SKU:
- RPES4155
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Epigenetics & Nuclear Signaling
Description
Human PPIase/FKBP7 Recombinant Protein
PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family; PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members of the immunophilin protein family play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It has a very high substrate specificity for the four-residue peptide Ala-Ala-Pro-Phe only when the proline peptide bond is in the trans state. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels; and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse; deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
| Product Name: | Human PPIase/FKBP7 Recombinant Protein (RPES4155) |
| Product Code: | RPES4155 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Peptidyl-Prolyl Cis-Trans Isomerase FKBP7, PPIase FKBP7, 23 kDa FK506-Binding Protein, 23 kDa FKBP, FKBP-23, FK506-Binding Protein 7, FKBP-7, Rotamase, FKBP7, FKBP23 |
| Accession: | Q9Y3C6 |
| Sequence: | Met 1-Gln218 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human FKBP7 (Q9Y680-2) (Met1-Gln218) was expressed with a polyhistidine tag at the C-terminus. |
| Purity: | (84.2+12.5) % as determined by reducing SDS-PAGE. |
| Mol Mass: | 23.8 kDa |
| AP Mol Mass: | 27-30 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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