Growth Factors & Cytokines Recombinant Proteins
Human PLGF3 Recombinant Protein (RPPB0868)
- SKU:
- RPPB0868
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P49763
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human PLGF3 Recombinant Protein |
| Product Code: | RPPB0868 |
| Size: | 25µg |
| Species: | Human |
| Target: | PLGF3 |
| Synonyms: | Placental Growth Factor, Placental Growth Factor Vascular Endothelial Growth Factor-Related Protein, PGFL, PLGF, Placental Growth Factor-Like, Placenta Growth Factor, SHGC-10760, D12S1900, PlGF-2, PGF. |
| Source: | Spodoptera frugiperda |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | PLGF-3 protein was lyophilized from a 0.2�m filtered solution in HCl. |
| Solubility: | It is recommended to reconstitute the lyophilized PLGF3 in sterile 4mM HCl not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized PLGF3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PLGF-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Biological Activity: | The ED50, as measured by its binding ability to rHuVEGF R1 in a functional ELISA, is less than 3ng/ml. |
PLGF is a growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor vegfr-1/flt1.
PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.The PLGF-3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: extracellular space; membrane; extracellular region Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation |
| NCBI Summary: | This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] |
| UniProt Code: | P49763 |
| NCBI GenInfo Identifier: | 17380553 |
| NCBI Gene ID: | 5228 |
| NCBI Accession: | P49763.2 |
| UniProt Secondary Accession: | P49763,Q07101, Q9BV78, Q9Y6S8, |
| UniProt Related Accession: | P49763 |
| Molecular Weight: | 19,338 Da |
| NCBI Full Name: | Placenta growth factor |
| NCBI Synonym Full Names: | placental growth factor |
| NCBI Official Symbol: | PGF�� |
| NCBI Official Synonym Symbols: | PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760�� |
| NCBI Protein Information: | placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein |
| UniProt Protein Name: | Placenta growth factor |
| Protein Family: | Placenta growth factor |
| UniProt Gene Name: | PGF�� |
| UniProt Entry Name: | PLGF_HUMAN |
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