Human PLEKHF2 Recombinant Protein (RPPB4260)
- SKU:
- RPPB4260
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H8W4
Description
| Product Name: | Human PLEKHF2 Recombinant Protein |
| Product Code: | RPPB4260 |
| Size: | 20µg |
| Species: | Human |
| Target: | PLEKHF2 |
| Synonyms: | EAPF, PHAFIN2, ZFYVE18, Pleckstrin homology domain-containing family F member 2, PH domain-containing family F member 2, Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains, PH and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 18, PLEKHF2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PLEKHF2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVDRLAN SEANTRRISI VENCFGAAGQ PLTIPGRVLI GEGVLTKLCR KKPKARQFFL FNDILVYGNI VIQKKKYNKQ HIIPLENVTI DSIKDEGDLR NGWLIKTPTK SFAVYAATAT EKSEWMNHIN KCVTDLLSKS GKTPSNEHAA VWVPDSEATV CMRCQKAKFT PVNRRHHCRK CGFVVCGPCS EKRFLLPSQS SKPVRICDFC YDLLSAGDMA TCQPARSDSY SQSLKSPLND MSDDDDDDDS SD |
Pleckstrin Homology Domain Containing Family F Member 2, also known as PLEKHF2, contains 1 FYVE-type zinc finger and 1 PH domain. PLEKHF2 takes part in early endosome fusion upstream of RAB5, regulates receptor trafficking and fluid-phase transport. PLEKHF2 increases cellular sensitivity to TNF-induced apoptosis.
PLEKHF2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 272 amino acids (1-249 a.a) and having a molecular mass of 30.2kDa. PLEKHF2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PLEKHF2: a protein containing a PH domain and a FYVE zinc finger domain. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: transport vesicle Molecular Function:protein binding |
| UniProt Code: | Q9H8W4 |
| NCBI GenInfo Identifier: | 74762744 |
| NCBI Gene ID: | 79666 |
| NCBI Accession: | Q9H8W4.1 |
| UniProt Related Accession: | Q9H8W4 |
| Molecular Weight: | 27,798 Da |
| NCBI Full Name: | Pleckstrin homology domain-containing family F member 2 |
| NCBI Synonym Full Names: | pleckstrin homology and FYVE domain containing 2 |
| NCBI Official Symbol: | PLEKHF2�� |
| NCBI Official Synonym Symbols: | EAPF; PHAFIN2; ZFYVE18�� |
| NCBI Protein Information: | pleckstrin homology domain-containing family F member 2 |
| UniProt Protein Name: | Pleckstrin homology domain-containing family F member 2 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains; EAPF; PH and FYVE domain-containing protein 2; Phafin-2; Phafin2; Zinc finger FYVE domain-containing protein 18 |
| Protein Family: | Pleckstrin homology domain-containing family |
| UniProt Gene Name: | PLEKHF2�� |
| UniProt Entry Name: | PKHF2_HUMAN |
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