Metabolism Recombinant Proteins
Human PLA2G7/Lp-PLA2 Recombinant Protein (RPES3449)
- SKU:
- RPES3449
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
Description
Human PLA2G7/Lp-PLA2 Recombinant Protein
Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presence of inflammatory bodily responses. PAFAH alters the action of PAF by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. PAFAH has specificity for substrates with a short residue at the sn-2 position.
| Product Name: | Human PLA2G7/Lp-PLA2 Recombinant Protein (RPES3449) |
| Product Code: | RPES3449 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | 2-acetyl-1-alkylglycerophosphocholine esterase, EC 3.1.1, EC 3.1.1.47,1-alkyl-2-acetylglycerophosphocholine esterase, Group-VIIA phospholipase A2, gVIIA-PLA2, LDL-associated phospholipase A2, LDL-PLA(2), LDL-PLA2, lipoprotein-associated phospholipase A2, LpPLA2, Lp-PLA2, PAF acetylhydrolase, PAF-AH, PAFAHPAF 2-acylhydrolase, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, PLA2G7, plasma), platelet-activating factor acetylhydrolase |
| Accession: | Q13093-1 |
| Sequence: | Phe22-Asn441 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Platelet-Activating Factor Acetylhydrolase is produced by our Mammalian expression system and the target gene encoding Phe22-Asn441 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 48.8 kDa |
| AP Mol Mass: | 54 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM HAc-NaCl; 150mM NaCl; 10% Glycerol; pH 4.5. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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