Metabolism Recombinant Proteins

Human PKLR Recombinant Protein (RPES3569)

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SKU:
RPES3569
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism

Description

system_update_altDatasheet

Human PKLR Recombinant Protein

Pyruvate Kinase Isozymes R/L (PKLR) belongs to the pyruvate kinase family, There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver; R is found in red cells; M1 is the main form in muscle, heart and brain; M2 is found in early fetal tissues. PKLR exists as a homotetramer and catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in PKLR are also the cause of pyruvate kinase deficiency of red cells, which is a frequent cause of hereditary non-spherocytic hemolytic anemia.

Product Name:Human PKLR Recombinant Protein (RPES3569)
Product Code:RPES3569
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Pyruvate Kinase Isozymes R/L, Pyruvate Kinase 1, R-Type/L-Type Pyruvate Kinase, Red Cell/Liver Pyruvate Kinase, PKLR, PK1, PKL
Accession:P30613
Sequence:Met 1-Ser574
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Pyruvate Kinase, Liver And RBC is produced by our Mammalian expression system and the target gene encoding Met1-Ser574 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:62.9 kDa
AP Mol Mass:58 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM Tris-HCl, 1mM DTT 0.2M NaCl, 10% glycerol, pH 8.0.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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