Growth Factors & Cytokines Recombinant Proteins

Human Pituitary Growth Hormone 22kDa Recombinant Protein (RPPB0325)

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SKU:
RPPB0325
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01242
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human Pituitary Growth Hormone 22kDa Recombinant Protein
Product Code:RPPB0325
Size:50µg
Species:Human
Target:Pituitary Growth Hormone 22kDa
Synonyms:GHL, GHV, GH-V, hGH-V, PGH.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3 previously adjusted pH 8-9.
Solubility:It is recommended to reconstitute the lyophilized Placental HGH in 0.4% NaHCO3or water adjusted to pH 9, not less than 100 �g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized GH placental although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization HGH placental can be stored at 4°C for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Phe-Pro-Thr-Ile

GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Placental HGH 22kDa Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 192 amino acids and having a molecular mass of 22367 Dalton. Predicted pI=7.80. Placental Growth Hormone has dimished lactogenic (prolactin receptor mediated) activity characteristic to pituitary GHs. GH Placental Human Recombinant is purified by proprietary chromatographic techniques.

UniProt Protein Function:GH2: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular region

NCBI Summary:The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]
UniProt Code:P01242
NCBI GenInfo Identifier:20141664
NCBI Gene ID:2689
NCBI Accession:P01242.3
UniProt Secondary Accession:P01242,O14643, O14644, P09587, B1A4H5, B1A4H7,
UniProt Related Accession:P01242
Molecular Weight:27,101 Da
NCBI Full Name:Growth hormone variant
NCBI Synonym Full Names:growth hormone 2
NCBI Official Symbol:GH2��
NCBI Official Synonym Symbols:GHL; GHV; GH-V; GHB2; hGH-V��
NCBI Protein Information:growth hormone variant
UniProt Protein Name:Growth hormone variant
UniProt Synonym Protein Names:Growth hormone 2; Placenta-specific growth hormone
Protein Family:Growth hormone
UniProt Gene Name:GH2��
UniProt Entry Name:SOM2_HUMAN
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