Human PITPNB Recombinant Protein (RPPB4254)
- SKU:
- RPPB4254
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P48739
Description
| Product Name: | Human PITPNB Recombinant Protein |
| Product Code: | RPPB4254 |
| Size: | 25µg |
| Species: | Human |
| Target: | PITPNB |
| Synonyms: | Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB, VIB1B, PtdInsTP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PITPNB solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET QKELETMRKR GSVRGTSAAD V |
Phosphatidylinositol transfer protein beta isoform (PITPNB) is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. PITPNB mobilizes PI from the endoplasmic reticulum and regulates its release from stored vesicles in the Golgi network. PITPNB is extensively expressed in various tissues.
PITPNB Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 291 amino acids (1-271 a.a.) and having a molecular mass of 33.7kDa. The PITPNB is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PITPNB: transfers phosphatidylinositol, phosphatidylcholine and sphingomyelin between membrane bilayers. Associates mainly with the trans-Golgi network. Ser-261 is constitutively phosphorylated.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 22q12.1Cellular Component: endoplasmic reticulum membrane; Golgi membraneBiological Process: phospholipid transport |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P48739 |
| NCBI GenInfo Identifier: | 1346772 |
| NCBI Gene ID: | 23760 |
| NCBI Accession: | P48739.2 |
| UniProt Secondary Accession: | P48739,Q8N5W1, B3KYB8, B7Z7Q0 |
| UniProt Related Accession: | P48739 |
| Molecular Weight: | 31,700 Da |
| NCBI Full Name: | Phosphatidylinositol transfer protein beta isoform |
| NCBI Synonym Full Names: | phosphatidylinositol transfer protein beta |
| NCBI Official Symbol: | PITPNB�� |
| NCBI Official Synonym Symbols: | VIB1B; PtdInsTP; PI-TP-beta�� |
| NCBI Protein Information: | phosphatidylinositol transfer protein beta isoform |
| UniProt Protein Name: | Phosphatidylinositol transfer protein beta isoform |
| UniProt Synonym Protein Names: | |
| Protein Family: | Phosphatidylinositol transfer protein |
| UniProt Gene Name: | PITPNB�� |
| UniProt Entry Name: | PIPNB_HUMAN |
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