Human PITPNA Recombinant Protein (RPPB4253)

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SKU:
RPPB4253
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q00169

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human PITPNA Recombinant Protein
Product Code:RPPB4253
Size:25µg
Species:Human
Target:PITPNA
Synonyms:Phosphatidylinositol transfer protein alpha isoform, PI-TP-alpha, PtdIns transfer protein alpha, PtdInsTP alpha, PITPNA, PITPN, VIB1A, MGC99649, PI-TPalpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PITPNA solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol, 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DGEKGQYTHK IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN EYMKEDFLIK IETWHKPDLG TQENVHKLEP EAWKHVEAVY IDIADRSQVL SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE LVNQKDCPYM CAYKLVTVKF KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM DDIRRMEEET KRQLDEMRQK DPVKGMTADD

Phosphatidylinositol transfer protein alpha (PITPNA) is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. PITPNA belongs to a family of lipid-binding proteins which transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. PITPNA is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) by phosphoinositide-3-kinase.

PITPNA Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 290 amino acids (1-270 a.a.) and having a molecular mass of 23.9kDa. The PITPNA is purified by proprietary chromatographic techniques.

UniProt Protein Function:PITPNA: Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
UniProt Protein Details:

Protein type:Lipid-binding

Chromosomal Location of Human Ortholog: 17p13.3

Molecular Function:phosphatidylcholine transmembrane transporter activity; phosphatidylinositol transporter activity

Biological Process: visual perception

NCBI Summary:This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]
UniProt Code:Q00169
NCBI GenInfo Identifier:130770
NCBI Gene ID:5306
NCBI Accession:Q00169.2
UniProt Secondary Accession:Q00169,P16446, P48738, P53810, Q2HJ54,
UniProt Related Accession:Q00169
Molecular Weight:31,806 Da
NCBI Full Name:Phosphatidylinositol transfer protein alpha isoform
NCBI Synonym Full Names:phosphatidylinositol transfer protein alpha
NCBI Official Symbol:PITPNA��
NCBI Official Synonym Symbols:PITPN; VIB1A; HEL-S-36; PI-TPalpha��
NCBI Protein Information:phosphatidylinositol transfer protein alpha isoform
UniProt Protein Name:Phosphatidylinositol transfer protein alpha isoform
Protein Family:Phosphatidylinositol transfer protein
UniProt Gene Name:PITPNA��
UniProt Entry Name:PIPNA_HUMAN
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system_update_altDatasheetHuman PITPNA Recombinant Protein Phosphatidylinositol Transfer Protein ? Isoform (PITPNA) is found in the cytoplasm and belongs to the PtdIns transfer protein family. PI