Metabolism Recombinant Proteins
Human PGD2 Synthase/PTGDS Recombinant Protein (RPES1366)
- SKU:
- RPES1366
Description
Human PGD2 Synthase/PTGDS Recombinant Protein
PTGDS; also known as L-PGDS; belongs to the calycin superfamily;lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids; bilins; retinoids; and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules; including biliverdin; bilirubin; retinal; retinoic acid and thyroid hormone; and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
| Product Name: | Human PGD2 Synthase/PTGDS Recombinant Protein (RPES1366) |
| Product Code: | RPES1366 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Prostaglandin D Synthase, Prostaglandin-H2 D-Isomerase, Beta-Trace Protein, Cerebrin-28, Glutathione-Independent PGD Synthase, Lipocalin-Type Prostaglandin-D Synthase, Prostaglandin-D2 Synthase, PGD2 Synthase,PGDS, PGDS2, PTGDS, PDS |
| Accession: | P41222 |
| Sequence: | Met 1-Gln190 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human PTGDS (P41222) (Met1-Gln190) was expressed with a polyhistidine tag at the C-terminus. |
| Purity: | > 80 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 20.1 kDa |
| AP Mol Mass: | 28 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Metabolism |
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