Cell Biology Recombinant Proteins

Human PDGFRa/CD140a Recombinant Protein (RPES0498)

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SKU:
RPES0498
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology

Description

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Human PDGFRa/CD140a Recombinant Protein

Platelet-derived Growth Factor Receptor Alpha (PDGF R?) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF R? is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF R? autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-? pathways. PDGF R? has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial ,cardiac neural crest and interstitial kidney mesenchyme.

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