Epigenetics & Nuclear Signaling Recombinant Proteins

Human PARP-3/PARP3 Recombinant Protein (RPES3016)

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RPES3016

Description

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Human PARP-3/PARP3 Recombinant Protein

Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.

Product Name:Human PARP-3/PARP3 Recombinant Protein (RPES3016)
Product Code:RPES3016
Size:20µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:ADPRT3,ADPRTL2,ADPRTL3,ARTD3,IRT1,PADPRT-3
Accession:Q9Y6F1-1
Sequence:Met 1-Leu 533
Fusion tag:N-His & GST
Endotoxin:<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:A DNA sequence encoding the C-terminal segment of human PARP3 isoform 1 (Q9Y6F1-1) (Met 1-Leu 533) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:87.8 kDa
AP Mol Mass:95 kDa
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Epigenetics & Nuclear Signaling
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