Immunology Recombinant Proteins

Human OX40/TNFRSF4 Recombinant Protein (RPES5037)

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SKU:
RPES5037
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology

Description

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Human OX40/TNFRSF4 Recombinant Protein

OX40; also termed CD134 andT NFRSF4; is a Tcellco-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells(APCs). TheT-cell functions; including cytokine production; expansion; and survival; are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance; peripheral T-cell homeostasis; and T-cell-mediated inflammatory diseases.

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