Metabolism Recombinant Proteins

Human NSE/ENO2 Recombinant Protein (RPES2591)

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RPES2591

Description

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Human NSE/ENO2 Recombinant Protein

Gamma-enolase; also known as Enolase 2; belongs to the enolase family. The alpha/alpha homodimer of ENO2 is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle; and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. During ontogenesis; there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells; and to the alpha/gamma heterodimer in nerve cells. Levels of ENO2 increase dramatically in cardiovascular accidents; cerebral trauma; brain tumors and Creutzfeldt-Jakob disease. ENO2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. It binds to cultured neocortical neurons and promotes cell survival in a calcium-dependent manner.

Product Name:Human NSE/ENO2 Recombinant Protein (RPES2591)
Product Code:RPES2591
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Gamma-enolase,2-phospho-D-glycerate hydro-lyase,Enolase 2,Neural enolase,Neuron-specific enolase,NSE,ENO2
Accession:P09104
Sequence:Met1-Leu434
Fusion tag:N-His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human NSE is produced by our E.coli expression system and the target gene encoding Met1-Leu434 is expressed with a 6His tag at the N-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:49.4 kDa
AP Mol Mass:55 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM Tris;100mM KCl;5mM MgSO4;pH 7.5.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Metabolism
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