Human NCR3/NKp30 Recombinant Protein (RPES2762)

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SKU:
RPES2762
Product Type:
Recombinant Protein
Species:
Human

Description

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Human NCR3/NKp30 Recombinant Protein

Natural Cytotoxicity Triggering Receptor 3; NCR3; also known as NKp30; or CD337; is a natural cytotoxicity receptor; expressed on subsets of human peripheral blood NK cells; involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive; but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity; and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.

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