Human NCR3/NKp30 Recombinant Protein (RPES2762)
- SKU:
- RPES2762
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human NCR3/NKp30 Recombinant Protein
Natural Cytotoxicity Triggering Receptor 3; NCR3; also known as NKp30; or CD337; is a natural cytotoxicity receptor; expressed on subsets of human peripheral blood NK cells; involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive; but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity; and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.
| Product Name: | Human NCR3/NKp30 Recombinant Protein (RPES2762) |
| Product Code: | RPES2762 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | Natural Cytotoxicity Triggering Receptor 3, Activating Natural Killer Receptor p30, Natural Killer Cell p30-Related Protein, NK-p30, NKp30, CD337, NCR3, 1C7, LY117,1C7,DAAP-90L16.3,MALS |
| Accession: | NP_667341.1 |
| Sequence: | Met 1-Gly 135 |
| Fusion tag: | C-His |
| Activity: | Measured by its binding ability in a functional ELISA. Immobilized human NCR3 at 10µg/mL (100?L/well) can bind human B7-H6 ; the EC50 of human B7-H6 is 20-100ng/mL. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Gly 135) of human NCR3 (NP_667341.1) precursor was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14.4 kDa |
| AP Mol Mass: | 22-28 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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