Human NAPA Recombinant Protein (RPPB4058)

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RPPB4058

Description

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Product Name:Human NAPA Recombinant Protein
Product Code:RPPB4058
Size:20µg
Species:Human
Target:NAPA
Synonyms:SNAPA, SNAP-alpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:NAPA protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN MFKMAKNWSA AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA INCLMRAIEI YTDMGRFTIA AKHHISIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAG YAALLEQYQK AIDIYEQVGT NAMDSPLLKY SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEAHEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR

NAPA is part of the SNAP (Soluble NSF Attachment Protein) family. SNAPs, acting together with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF), are necessary for the fusion of transport vesicles to their objective membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. NAPA is in charge of the binding of NSF and therefore the formation of a 20S fusion particle.

NAPA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 315 amino acids (1-295) and having a molecular mass of 35.3 kDa. NAPA is fused to 20 amino acid His Tag at N-terminus and purified by standard chromatography techniques.

UniProt Protein Function:Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane (PubMed:15980433).
NCBI Summary:This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
UniProt Code:P54920
NCBI GenInfo Identifier:47933379
NCBI Gene ID:8775
NCBI Accession:NP_003818.2
UniProt Secondary Accession:P54920,Q96IK3, Q9BVJ3, A8K879,
UniProt Related Accession:P54920
Molecular Weight:33kDa
NCBI Full Name:alpha-soluble NSF attachment protein
NCBI Synonym Full Names:NSF attachment protein alpha
NCBI Official Symbol:NAPA��
NCBI Official Synonym Symbols:SNAPA��
NCBI Protein Information:alpha-soluble NSF attachment protein
UniProt Protein Name:Alpha-soluble NSF attachment protein
UniProt Synonym Protein Names:N-ethylmaleimide-sensitive factor attachment protein alpha
Protein Family:Na(+)/H(+) antiporter
UniProt Gene Name:NAPA��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P54920
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