Signal Transduction Recombinant Proteins

Human NACHRA5/CHRNA5 Recombinant Protein (RPES0832)

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SKU:
RPES0832
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Signal Transduction

Description

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Human NACHRA5/CHRNA5 Recombinant Protein

Neuronal Acetylcholine Receptor Subunit ?-5 (NACHRA5) is a member of the ligand-gated ion channel family. Neuronal AChR is composed of two different type of subunits: ? and non-?. When NACHRA5 binds to acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits, leading to the opening of an ion-conducting channel across the plasma membrane. Genetic variations in NACHRA5 have been related to susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3.

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