Growth Factors & Cytokines Recombinant Proteins

Human Myostatin Recombinant Protein (RPPB0778)

(No reviews yet) Write a Review
SKU:
RPPB0778
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O14793
Research Area:
Growth Factors & Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human Myostatin Recombinant Protein
Product Code:RPPB0778
Size:10µg
Species:Human
Target:Myostatin
Synonyms:GDF-8, MSTN, Growth/Differentiation Factor 8,MSTN Muscle Hypertrophy.
Source:Escherichia Coli
Physical Appearance:Filtered white lyophilized (freeze-dried) powder.
Formulation:Filtered (0.4�m) and lyophilized from 0.5mg/ml in 0.05M acetate buffer, pH 4.5.
Solubility:Add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDPSSRSAVR SRRDFGLDCD EHSTESRCCR YPLTVDFEAFGWDWIIAPKR YKANYCSGEC EFVFLQKYPH THLVHQANPR GSAGPCCTPT KMSPINMLYF NGKEQIIYGKIPAMVVDRCG CS

Myostatin (GDF-8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma.

Total 152AA. M.W. 16.7kDa (calculated). N-terminal His-tag and spacer (43AA � highlighted). The AA sequence of the human myostatin part of the fusion protein is corresponding to the UniProtKB/Swiss-Prot entry O14793.

UniProt Protein Function:MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space

Molecular Function:cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding

Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Muscle Hypertrophy

UniProt Code:O14793
NCBI GenInfo Identifier:4885259
NCBI Gene ID:2660
NCBI Accession:NP_005250.1
UniProt Secondary Accession:O14793,Q6B0H2, A1C2J7, A1C2K0,
UniProt Related Accession:O14793
Molecular Weight:42,750 Da
NCBI Full Name:growth/differentiation factor 8 preproprotein
NCBI Synonym Full Names:myostatin
NCBI Official Symbol:MSTN��
NCBI Official Synonym Symbols:GDF8; MSLHP��
NCBI Protein Information:growth/differentiation factor 8
UniProt Protein Name:Growth/differentiation factor 8
UniProt Synonym Protein Names:Myostatin
Protein Family:Growth/differentiation factor
UniProt Gene Name:MSTN��
UniProt Entry Name:GDF8_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products