Growth Factors & Cytokines Recombinant Proteins

Human Myostatin Propeptide Recombinant Protein (RPPB0780)

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SKU:
RPPB0780
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O14793
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human Myostatin Propeptide Recombinant Protein
Product Code:RPPB0780
Size:25µg
Species:Human
Target:Myostatin Propeptide
Synonyms:GDF-8, MSTN, Growth Differentiation Factor 8, MSTN Muscle Hypertrophy.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered white lyophilized (freeze-dried) powder.
Formulation:Lyophilized with no additives.
Solubility:It is recommended to reconstitute the lyophilized Myostatin Propeptide in sterile 20mM HCl at 0.1mg/ml, which can then be further diluted to other aqueous solutions.�
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRR
Biological Activity:The protein has full biological activity when compared to a standard. The activity is determined by its ability to inhibit 50ng/ml of Myostatin on MPC-11 cells and is typically 0.13-0.2 ?g/ml.

Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.

Recombinant Human Myostatin Propeptide is a 27.8kDa protein containing 244 amino acid residues of the human Myostatin Propeptide.

UniProt Protein Function:MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space

Molecular Function:cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding

Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Muscle Hypertrophy

UniProt Code:O14793
NCBI GenInfo Identifier:4885259
NCBI Gene ID:2660
NCBI Accession:NP_005250.1
UniProt Secondary Accession:O14793,Q6B0H2, A1C2J7, A1C2K0,
UniProt Related Accession:O14793
Molecular Weight:42,750 Da
NCBI Full Name:growth/differentiation factor 8 preproprotein
NCBI Synonym Full Names:myostatin
NCBI Official Symbol:MSTN��
NCBI Official Synonym Symbols:GDF8; MSLHP��
NCBI Protein Information:growth/differentiation factor 8
UniProt Protein Name:Growth/differentiation factor 8
UniProt Synonym Protein Names:Myostatin
Protein Family:Growth/differentiation factor
UniProt Gene Name:MSTN��
UniProt Entry Name:GDF8_HUMAN
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