Human MMP-3 Recombinant Protein (RPES2942)

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SKU:
RPES2942
Product Type:
Recombinant Protein
Species:
Human

Description

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Human MMP-3 Recombinant Protein

Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a matrix metalloproteinase (MMP) member that plays a role in the breakdown of extracellular matrix during normal physiological functions such as embryonic development, reproduction, tissue regeneration, and disease processes including arthritis and metastasis. MMP3 acts in the extracellular matrix as a secreted zinc-dependent endopeptidase. Alpha2-macroglobulin and tissue metalloproteinase inhibitors (TIMPs) are two major endogenous inducers that activate this protein. Collagen types II, III, IV, IX, and X are all targeted by MMP3. It also targets proteoglycans, fibronectin, laminin, and elastin. MMP3 may also activate other MMPs, including MMP1, MMP7, and MMP9, which is why it's so important in connective tissue remodeling. MMPs are implicated in a variety of diseases, including arthritis, chronic ulcers, encephalomyelitis, and cancer. Synthetic or natural MMPs inhibitors decrease metastasis, whereas up-regulation of MMPs promotes cancer cell invasion. Human MMP-3 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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