Growth Factors & Cytokines Recombinant Proteins

Human MIA2 Recombinant Protein (RPPB0769)

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SKU:
RPPB0769
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96PC5
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human MIA2 Recombinant Protein
Product Code:RPPB0769
Size:20µg
Species:Human
Target:MIA2
Synonyms:MIA-2, MIA2, Melanoma Inhibitory Activity 2, FLJ22404.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The MIA2 protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Phosphate buffer pH=7.4 and 150mM NaCl.
Solubility:It is recommended to reconstitute the lyophilized MIA2 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized MIA2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MIA2 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MLESTKLLAD LKKCGDLECE ALINRVSAMR DYRGPDCRYL NFTKGEEISV YVKLAGERED LWAGSKGKEF GYFPRDAVQI EEVFISEEIQ MSTKESDFLC L

MIA2 performs as a tumour suppressor in hepatocellular carcinoma. MIA2is a novel acute phase protein which its expression is found in the liver and reacts to liver damage in chronic liver diseases and is considerably higher in severe fibrosis patients . MIA2 is induced by IL6, TGF-B & and conditioned medium from activated hepatic stellate cells. MIA2 is is mainly expressed in hepatocytes.

MIA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 101 amino having a total molecular mass of 11.5 kDa.The MIA2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:MIA2: May play a role in the pathophysiology of liver disease and may serve as a marker of liver damage. Belongs to the MIA/OTOR family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 14q13.2Cellular Component: extracellular regionBiological Process: cholesterol homeostasis
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q96PC5
NCBI GenInfo Identifier:308153584
NCBI Gene ID:117153
NCBI Accession:Q96PC5.3
UniProt Secondary Accession:Q96PC5,Q9H6C1, A1L4H0
UniProt Related Accession:Q96PC5
Molecular Weight:74,089 Da
NCBI Full Name:Melanoma inhibitory activity protein 2
NCBI Synonym Full Names:melanoma inhibitory activity 2
NCBI Official Symbol:MIA2��
NCBI Official Synonym Symbols:
NCBI Protein Information:melanoma inhibitory activity protein 2
UniProt Protein Name:Melanoma inhibitory activity protein 2
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:MIA2��
UniProt Entry Name:MIA2_HUMAN
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