Cell Biology Recombinant Proteins
Human Mesothelin/MSLN Recombinant Protein (RPES4488)
- SKU:
- RPES4488
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
Description
Human Mesothelin/MSLN Recombinant Protein
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura; pericardium; and peritoneum) and epithelial cells of the trachea; tonsils; fallopian tube; and kidneys. Mesothelin plays an important role in cell survival; proliferation; migration; invasion; tumor progression; and resistance to chemotherapy. The overexpression of mesothelin can activate NF-?B and signal transducer and activator of transcription 3 (Stat3); inhibit apoptotic signaling and TNF-?-induced apoptosis; and accelerate the G1S transition. Mesothelin is also found overexpressed in various cancers; including malignant mesothelioma; pancreatic or ovarian carcinoma; sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues; mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.
| Product Name: | Human Mesothelin/MSLN Recombinant Protein (RPES4488) |
| Product Code: | RPES4488 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Megakaryocyte potentiating factor, mesothelin, Pre-pro-megakaryocyte-potentiating factor, soluble MPF mesothelin related protein,CAK1, MPF, MSLN, SMR, CAK1, CAK1 antigen |
| Accession: | Q13421 |
| Sequence: | Leu37-Arg286 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Mesothelin is produced by our Mammalian expression system and the target gene encoding Leu37-Arg286 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 27.8 kDa |
| AP Mol Mass: | 30-35 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Related Products
Human Mesothelin/MSLN Recombinant Protein (RPES4510)
Cell Biology Recombinant Proteins
Human Mesothelin/MSLN Recombinant Protein (RPES1670)
Cell Biology Recombinant Proteins
Human Mesothelin/MSLN Recombinant Protein (RPES1086)
Cell Biology Recombinant Proteins
Human Mesothelin/MSLN Recombinant Protein (RPES4466)
Cell Biology Recombinant Proteins
Human Mesothelin/MSLN Recombinant Protein (RPES1067)
Cell Biology Recombinant Proteins