Cell Biology Recombinant Proteins

Human Mesothelin/MSLN Recombinant Protein (RPES4488)

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SKU:
RPES4488
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology

Description

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Human Mesothelin/MSLN Recombinant Protein

Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura; pericardium; and peritoneum) and epithelial cells of the trachea; tonsils; fallopian tube; and kidneys. Mesothelin plays an important role in cell survival; proliferation; migration; invasion; tumor progression; and resistance to chemotherapy. The overexpression of mesothelin can activate NF-?B and signal transducer and activator of transcription 3 (Stat3); inhibit apoptotic signaling and TNF-?-induced apoptosis; and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers; including malignant mesothelioma; pancreatic or ovarian carcinoma; sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues; mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.

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