Chemokines Recombinant Proteins

Human LAG-1 Recombinant Protein (RPPB1179)

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SKU:
RPPB1179
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8NHW4
Research Area:
Chemokines

Description

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Product Name:Human LAG-1 Recombinant Protein
Product Code:RPPB1179
Size:20µg
Species:Human
Target:LAG-1
Synonyms:C-C motif chemokine 4-like, Lymphocyte activation gene 1 protein, LAG-1, Macrophage inflammatory protein 1-beta, MIP-1-beta, Monocyte adherence-induced protein 5-alpha, Small-inducible cytokine A4-like, CCL4L1, CCL4L, LAG1, SCYA4L1, CCL4L2, SCYA4L2, AT744.2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:LAG-1 was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized LAG-1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized LAG-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL4L1 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
Biological Activity:The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of > 5.0 � 105 IU/mg.

CCL4L1 (C-C motif chemokine 4-like) is a member of to intercrine beta (chemokine CC) family. The CCL4L1 protein is similar to CCL4 which inhibits HIV replication in peripheral blood monocytes which express CCR5.

LAG-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 69 amino acids and having a molecular mass of 7.8kDa.The CCL4L1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL4L1: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Belongs to the intercrine beta (chemokine CC) family. 10 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

NCBI Summary:This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Code:Q8NHW4
NCBI GenInfo Identifier:74727347
NCBI Gene ID:9560
NCBI Accession:Q8NHW4.1
UniProt Secondary Accession:Q8NHW4,Q50EM1, Q50EM2, Q50EM3, Q50EM4, Q50EM5, Q50EM6 Q50EM7, Q50EM8, Q569J2, B2RUZ3, B7ZMA8,
Molecular Weight:11,008 Da
NCBI Full Name:C-C motif chemokine 4-like
NCBI Synonym Full Names:chemokine (C-C motif) ligand 4-like 2
NCBI Official Symbol:CCL4L2��
NCBI Official Synonym Symbols:CCL4L; SCYA4L; AT744.2; SCYQ4L2��
NCBI Protein Information:C-C motif chemokine 4-like
UniProt Protein Name:C-C motif chemokine 4-like
UniProt Synonym Protein Names:Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL4L1��
UniProt Entry Name:CC4L_HUMAN
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