Cynomolgus LAG-3/CD223 Recombinant Protein (RPES2511)
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- SKU:
- RPES2511
- Product Type:
- Recombinant Protein
- Species:
- Monkey
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Description
system_update_altDatasheet
Cynomolgus LAG-3/CD223 Recombinant Protein
Lymphocyte Activating 3(LAG3) belongs to immunoglobulin (Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence, a 451 aa extracellular domain (ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.
| Product Name: | Cynomolgus LAG-3/CD223 Recombinant Protein (RPES2511) |
| Product Code: | RPES2511 |
| Size: | 10µg |
| Species: | Cynomolgus |
| Expressed Host: | Human Cells |
| Synonyms: | Lymphocyte Activating 3, LAG3, LAG-3, CD223 |
| Accession: | XP_005570011.1 |
| Sequence: | Pro23-Leu450(Pro74) |
| Fusion tag: | N-His |
| Activity: | Immobilized Cynomolgus LAG-3-His at 2µg/ml(100 ?l/well) can bind Human FGL1-Fc. The ED50 of Cynomolgus LAG-3-His is 5.8 ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Cynomolgus LAG-3 is produced by our Mammalian expression system and the target gene encoding Pro23-Leu450(Pro74) is expressed with a 8His tag at the N-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 47.3 kDa |
| AP Mol Mass: | 55-65&140 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS,PH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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