Chemokines Recombinant Proteins

Human LAG-1 Recombinant Protein (RPPB1178)

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SKU:
RPPB1178
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8NHW4
Research Area:
Chemokines

Description

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Product Name:Human LAG-1 Recombinant Protein
Product Code:RPPB1178
Size:20µg
Species:Human
Target:LAG-1
Synonyms:C-C motif chemokine 4-like, Lymphocyte activation gene 1 protein, LAG-1, Macrophage inflammatory protein 1-beta, MIP-1-beta, Monocyte adherence-induced protein 5-alpha, Small-inducible cytokine A4-like, CCL4L1, CCL4L, LAG1, SCYA4L1, CCL4L2, SCYA4L2, AT744.2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LAG-1 protein solution (0.5mg/ml) containing 10mM sodium citrate (pH 3.5) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAPMGS DPPTACCFSY TARKLPRNFV VDYYETSSLC SQPAVVFQTK RGKQVCADPS ESWVQEYVYD LELN

CCL4L1 (C-C motif chemokine 4-like) is a member of to intercrine beta (chemokine CC) family. The CCL4L1 protein is similar to CCL4 which inhibits HIV replication in peripheral blood monocytes which express CCR5.

LAG-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 94 amino acids (24-92 a.a.) and having a molecular mass of 10.5kDa (Molecular weight on SDS-PAGE will appear higher).LAG-1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL4L1: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Belongs to the intercrine beta (chemokine CC) family. 10 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

NCBI Summary:This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. This gene copy contains a non-consensus splice acceptor site at the 3' terminal exon found in other highly similar gene copies, and it thus uses other alternative splice sites for the 3' terminal exon, resulting in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Code:Q8NHW4
NCBI GenInfo Identifier:74727347
NCBI Gene ID:9560
NCBI Accession:Q8NHW4.1
UniProt Secondary Accession:Q8NHW4,Q50EM1, Q50EM2, Q50EM3, Q50EM4, Q50EM5, Q50EM6 Q50EM7, Q50EM8, Q569J2, B2RUZ3, B7ZMA8,
Molecular Weight:11,008 Da
NCBI Full Name:C-C motif chemokine 4-like
NCBI Synonym Full Names:chemokine (C-C motif) ligand 4-like 2
NCBI Official Symbol:CCL4L2��
NCBI Official Synonym Symbols:CCL4L; SCYA4L; AT744.2; SCYQ4L2��
NCBI Protein Information:C-C motif chemokine 4-like
UniProt Protein Name:C-C motif chemokine 4-like
UniProt Synonym Protein Names:Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL4L1��
UniProt Entry Name:CC4L_HUMAN
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