Human KLRC3 Recombinant Protein (RPPB3804)

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SKU:
RPPB3804
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q07444

Description

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Product Name:Human KLRC3 Recombinant Protein
Product Code:RPPB3804
Size:20µg
Species:Human
Target:KLRC3
Synonyms:Killer Cell Lectin-Like Receptor Subfamily C Member 3, NK Cell Receptor E, NKG2-E Type II Integral Membrane Protein, NKG2-E-Activating NK Receptor, NKG2E.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The KLRC3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMIPFLEQ NNSSPNTRTQ KARPCGHCPE EWITYSNSCY YIGKERRTWE ESLQACASKN SSSLLSIDNE EEMKFLASIL PSSWIGVFRN SSHHPWVTIN GLAFKHEIKD SDHAERNCAM LHVRGLISDQ CGSSRIIRRG FIMLTRLVLN S

KLRC3 belongs to the NKG2 group that can be found mostly in natural killer (NK) cells and encodes a family of transmembrane proteins known for their C-type lectin domain and their type II membrane orientation (extracellular C terminus). The NKG2 gene family is situated inside the NK complex, a region which has quite a few C-type lectin genes mostly expressed on NK cells.

KLRC3 Human Recombinant produced in E. coli is a single polypeptide chain containing 171 amino acids (94-240) and having a molecular mass of 19.0 kDa.KLRC3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:KLRC3: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: integral to membraneMolecular Function: transmembrane receptor activity; carbohydrate bindingBiological Process: cellular defense response; signal transduction
UniProt Protein Details:
NCBI Summary:Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q07444
NCBI GenInfo Identifier:75709175
NCBI Gene ID:3823
NCBI Accession:NP_002252
UniProt Secondary Accession:Q07444
UniProt Related Accession:Q07444
Molecular Weight:27kDa
NCBI Full Name:NKG2-E type II integral membrane protein isoform E
NCBI Synonym Full Names:killer cell lectin like receptor C3
NCBI Official Symbol:KLRC3��
NCBI Official Synonym Symbols:NKG2E; NKG2-E��
NCBI Protein Information:NKG2-E type II integral membrane protein
UniProt Protein Name:NKG2-E type II integral membrane protein
UniProt Synonym Protein Names:NK cell receptor E; NKG2-E-activating NK receptor
Protein Family:NKG2-E type II integral membrane protein
UniProt Gene Name:KLRC3��
UniProt Entry Name:NKG2E_HUMAN
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