Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein and KLK8, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. It regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Kallikrein-8 / KLK8 is expressed at high levels in serum, ascites fluid and tumor cytosol of advanced stage ovarian cancer patients and may serve as a marker of ovarian cancer. Kallikrein-8 / KLK8 may have potential clinical value for disease diagnosis or prognosis and it may also be a useful therapeutic target.
Product Name:
Human KLK-8/Kallikrein-8 Recombinant Protein (RPES0539)
Measured by its ability to cleave the fluorogenic peptide substrate BocVPRAMC. The specific activity is > 400pmoles/min/µg
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human KLK8 isoform 1 (O60259-1) (Met 1-Gly 260) was expressed, with a polyhistidine tag at the C-terminus.
Purity:
> 98 % as determined by reducing SDS-PAGE.
Mol Mass:
26.4 kDa
AP Mol Mass:
36 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetHuman KLK-8/Kallikrein-8 Recombinant Protein Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many K
system_update_altDatasheetHuman Kallikrein 4/KLK4 Recombinant Protein Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4,
system_update_altDatasheetHuman Kallikrein 6/KLK6 Recombinant Protein KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikre
system_update_altDatasheetHuman Kallikrein 2/KLK2 Recombinant Protein Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 conta
system_update_altDatasheetHuman Kallikrein 11/KLK11 Recombinant Protein kallikrein-related peptidase 11 (KLK11); also known as hippostasin; trypsin-like serine protease and PRSS20; is a member of
system_update_altDatasheetHuman Kallikrein 13/KLK13 Recombinant Protein Tissue kallikrein 13 (hK13); also known as KLK-L4 (kallikrein-like gene 4); is a member of the human tissue kallikrein fami
system_update_altDatasheetHuman Kallikrein 6/KLK6 Recombinant Protein Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Ka
system_update_altDatasheetHuman Kallikrein 5/KLK5 Recombinant Protein Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Ka
system_update_altDatasheetHuman Kallikrein 4/KLK4 Recombinant Protein Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Ka
