Human Kallikrein 7/KLK7 Recombinant Protein (RPES3940)

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SKU:
RPES3940
Product Type:
Recombinant Protein
Species:
Human

Description

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Human Kallikrein 7/KLK7 Recombinant Protein

Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

Product Name:Human Kallikrein 7/KLK7 Recombinant Protein (RPES3940)
Product Code:RPES3940
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Kallikrein-7, hK7, Serine Protease 6, Stratum Corneum Chymotryptic Enzyme, hSCCE, KLK7, PRSS6, SCCE
Accession:P49862
Sequence:Glu23-His252
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Kallikrein 7 is produced by our Mammalian expression system and the target gene encoding Glu23-His252 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:26.2 kDa
AP Mol Mass:30 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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